ACYLATED PIPERIDIHES AS GLYCINE TRANSPORTER INHIBITORS

The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, i...

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Hauptverfasser: EVANS, BRIAN, COULTON, STEVEN, GILPIN, MARTIN, LEONARD, MARSHALL, HOWARD, ROBERT, BRANCH, CLIVE, LESLIE, WARD, SIMON, EDWARD, DEAN, ANTHONY, WILLIAM, GOUGH, SHARON, LISA, BRADLEY, DANIEL, MARCUS, MACRITCHIE, JACQUELINE, ANNE, NASH, DAVID, JOHN, PORTER, RODERICK, ALAN, DOYLE, PAUL, MARTIN, CHAN, WAI, NGOR
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia. L'invention concerne un composé de la formule (I) ou un sel ou un solvate de celui-ci : où R1, n, X, Y et Z sont tels que définis dans la description, et les utilisations de tels composés. Les composés inhibent les transporteurs de GlyT1 et sont utiles dans le traitement de certains troubles neurologiques et neuropsychiatriques, y compris la schizophrénie.