PROCESS FOR THE PREPARATION OF IRINOTECAN HYDROCHLORIDE
The present invention is directed to a novel method for the preparation of high purity irinotecan hydrochloride. This can be achieved by eliminating the excess of the other reagent, bipi?eridinyl-1' -carbonyl chloride after it has reacted with 7-ethyl-10-hydroxy camptothecin and crystallizing t...
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| Format: | Patent |
| Sprache: | eng ; fre |
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| Zusammenfassung: | The present invention is directed to a novel method for the preparation of high purity irinotecan hydrochloride. This can be achieved by eliminating the excess of the other reagent, bipi?eridinyl-1' -carbonyl chloride after it has reacted with 7-ethyl-10-hydroxy camptothecin and crystallizing the final product from a suitable solvent.
Procédé d'élaboration d'irinotécane de haute pureté, par élimination de l'autre réactif en excès, chlorure de bipipéridinyl-1'-carbonyl, après la réaction avec 7-éthyl-10-hydroxy camptothécine, et cristallisation du produit final à partir d'un solvant approprié. |
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