ENZYMATIC PREPARATION OF AN INTERMEDIATE COMPOUND FOR THE SYNTHESIS OF TAMSULOSIN

ENZYMATIC PREPARATION OF AN INTERMEDIATE COMPOUND FOR THE SYNTHESIS OF TAMSULOSIN

The present invention relates to a process of enantioselective enzymatic acylation for the preparation of (R)-2-halo-N-[2-(4-methoxyphenyl)-1-methyl-ethyl] aceta-mide compounds, of formula III, in which X= Cl, Br, I. These compounds (III) are useful as intermediates in the synthesis of tamsulosin hy...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PALOMO NICOLAU, FRANCISCO, VILLASANTE PRIETO, JAVIER
Format: Patent
Sprache:eng ; fre
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The present invention relates to a process of enantioselective enzymatic acylation for the preparation of (R)-2-halo-N-[2-(4-methoxyphenyl)-1-methyl-ethyl] aceta-mide compounds, of formula III, in which X= Cl, Br, I. These compounds (III) are useful as intermediates in the synthesis of tamsulosin hydrochloride. L'invention se rapporte à un processus d'acylation enzymatique énantiosélective permettant de préparer des composés de (R)-2-halo-N-[2-(4-méthoxyphényl)-1-méthyl-éthyl] acétamide, représentés par la formule III, dans laquelle X= Cl, Br, I. Ces composés (III) sont utiles en tant qu'intermédiaires pour la synthèse de chlorhydrate de tamsulosine.