BINDING PROTEINS SPECIFIC FOR HUMAN MATRIPTASE

Binding proteins, such as fully human monoclonal antibodies and fragments thereof, directed to the antigen Matriptase and uses of such binding proteins are disclosed. Nucleotide sequences encoding, and amino acid sequences comprising heavy and light chain immunoglobulin molecules capable of binding...

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Hauptverfasser:	KEYT, BRUCE, A, KING, CHADWICK, LING, PETER, KOON BONG, MADISON, EDWIN, KANG, JASPAL, SINGH, FOLTZ, IAN, MORKOWSKI, STANISLAW, K, MANCHULENKO, KATHY, CHEN, FRANCINE, SCATENA, CAROLINE, DARNE, GODFREY, WAYNE, R, RICHARDSON, JENNIFER, H
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Binding proteins, such as fully human monoclonal antibodies and fragments thereof, directed to the antigen Matriptase and uses of such binding proteins are disclosed. Nucleotide sequences encoding, and amino acid sequences comprising heavy and light chain immunoglobulin molecules capable of binding to Matriptase are also disclosed. The invention also discloses cell lines expressing such immunoglobulin molecules and monoclonal antibodies to Matriptase. The antibodies can be used to treat diseases such as cancer. L'invention concerne des protéines de liaison telles que des anticorps monoclonaux entièrement humains et des fragments de ceux-ci dirigés contre l'antigène matriptase, et des utilisations de ces protéines de liaison. L'invention concerne aussi les séquences nucléotidiques codant pour les molécules d'immunoglobuline à chaînes lourdes et légères pouvant se lier à la matriptase, et les séquences d'acides aminés comprenant lesdites molécules. L'invention concerne en outre des lignées cellulaires exprimant ces molécules d'immunoglobuline et des anticorps monoclonaux dirigés contre la matriptase. Ces anticorps sont utiles dans le traitement de maladies telles que le cancer.