USE OF QUANTITATIVE EEG (QEEG) ALONE AND/OR OTHER IMAGING TECHNOLOGY AND/OR IN COMBINATION WITH GENOMICS AND/OR PROTEOMICS AND/OR BIOCHEMICAL ANALYSIS AND/OR OTHER DIAGNOSTIC MODALITIES

USE OF QUANTITATIVE EEG (QEEG) ALONE AND/OR OTHER IMAGING TECHNOLOGY AND/OR IN COMBINATION WITH GENOMICS AND/OR PROTEOMICS AND/OR BIOCHEMICAL ANALYSIS AND/OR OTHER DIAGNOSTIC MODALITIES

This invention relates to a method for significantly increasing the accuracy of predicting and selecting an antidepressant agent, or other pharmacological agent for treatment of a disease state, that will be effective based on pre-treatment or baseline, placebo treatment and/or active treatment, or...

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Bibliographische Detailangaben
Hauptverfasser: RABINOFF, MICHAEL, FUNG, KAISER
Format: Patent
Sprache:eng ; fre
Schlagworte:
CALCULATING
COMPUTING
COUNTING
DATA PROCESSING SYSTEMS OR METHODS, SPECIALLY ADAPTED FORADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL, SUPERVISORYOR FORECASTING PURPOSES
HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA
INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS
PHYSICS
SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE,COMMERCIAL, FINANCIAL, MANAGERIAL, SUPERVISORY OR FORECASTINGPURPOSES, NOT OTHERWISE PROVIDED FOR
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Beschreibung
Zusammenfassung:This invention relates to a method for significantly increasing the accuracy of predicting and selecting an antidepressant agent, or other pharmacological agent for treatment of a disease state, that will be effective based on pre-treatment or baseline, placebo treatment and/or active treatment, or other post-treatment time period data, early changes quantitative EEG or other brain imaging functional state and/or anatomical data (such as magnetoencephalography (MEG), quantitative MEG (QMEG), fMRI, CAT scan, PET, functional PET, X-ray, etc.), time change/time series, weighted factor, principal component, regional ensemble and/or artificial intelligence analysis. Utilization of such methods may also be applied to enhance individual statement verification and/or lie detection. In addition, such methods can be used to identify physiological state, pathophysiological state, including disease diagnosis, disease progression and/or remission, and other health and/or disease states and changes of interest. Furthermore, the invention may be used to discover novel applications for therapeutic entities, deduce the mode of action of one or more therapeutic entities, improve testing of candidate therapeutic entities, and be used by the pharmaceutical industry or research community to eliminate or select agents or therapeutic modalities for further development as therapeutic agents or treatment modalities. L'invention concerne un procédé permettant d'augmenter de manière notable la précision de prédiction et de sélection d'un antidépresseur, ou d'un autre agent pharmacologique pour le traitement d'un état pathologique, qui est efficace en étant fondé sur des données de prétraitement ou de traitement de ligne de base, de traitement placebo et/ou de traitement actif, ou d'autres données temporelles post-traitement, des données d'EEG quantitatif à changements précoces ou d'autres données d'état fonctionnel d'imagerie cérébrale et/ou des données anatomiques (de type magnétoencéphalographie (MEG), MEG quantitative (QMEG), IRM fonctionnelle, tomodensitogramme, tomogramme par émission de positons, tomogramme par émission de positons fonctionnel, rayon X, etc.), l'analyse de changement temporel/série temporelle, de facteur pondéré, de composant principal, d'ensemble régional et/ou d'intelligence artificielle. Lesdits procédés peuvent également être utilisés pour perfectionner la vérification d'informations personnelles et/ou la détection de mensonge. En outre, lesdits procédés p