PHENYLPIPERAZINES WITH A COMBINATION OF AFFINITY FOR DOPAMINE -D2 RECEPTORS AND SEROTONIN REUPTAKE SITES

The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and affinity for dopamine -D2 receptors and to methods for the preparation of these compounds. The invention also relates to the use of a compound disclosed herein for the...

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Bibliographische Detailangaben
Hauptverfasser:	TULP, MARTINUS TH.M, VAN HES, ROELOF, SMID, PIETER, KRUSE, CORNELIS G
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and affinity for dopamine -D2 receptors and to methods for the preparation of these compounds. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula ( 1 ) wherein the symbols have the meanings given in the specification. L'invention concerne un groupe de nouveaux dérivés de phénylpipérazine ayant un double mode d'action: réabsorption de la sérotonine et inhibition de récepteurs de la dopamine D2, ainsi que des procédés permettant de préparer lesdits composés. L'invention concerne également l'utilisation d'un composé décrit ici même, utilisé pour produire un médicament à effet bénéfique. Lesdits composés sont de formule (I) dans laquelle les symboles ont les significations de la description.