A PROCESS FOR THE PREPARATION OF N-DEMETHYLOLANZAPINE
The invention relates to the process for the preparation of N- demethylolanzapine and the use of N-demethylolanzapine obtained by the process for the preparation of antipsychotic medicament olanzapine. According to the process of the invention the reaction of an- hydrous piperazine with 4-amino-2-me...
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| creator | MAJKA, ZBIGNIEW STAWINSKI, TOMASZ RECHNIO, JUSTYNA |
| description | The invention relates to the process for the preparation of N- demethylolanzapine and the use of N-demethylolanzapine obtained by the process for the preparation of antipsychotic medicament olanzapine. According to the process of the invention the reaction of an- hydrous piperazine with 4-amino-2-methyl-10H-thieno[2.3-b]- [1.5]benzodiazepine or its inorganic acid addition salt is carried out in molten piperazine, in the absence of a solvent.
L'invention concerne le procédé de préparation de N-déméthylolanzapine, ainsi que l'utilisation de la N-déméthylolanzapine obtenue par ce procédé pour préparer un médicament antipsychotique, l'olanzapine. Selon ce procédé, la réaction de pipérazine anhydre avec de la 4-amino-2-méthyl-10H-thiéno[2.3-b]-[1.5]benzodiazépine ou son sel d'addition d'acide inorganique est réalisée dans de la pipérazine fondue, en l'absence de solvant. |
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L'invention concerne le procédé de préparation de N-déméthylolanzapine, ainsi que l'utilisation de la N-déméthylolanzapine obtenue par ce procédé pour préparer un médicament antipsychotique, l'olanzapine. Selon ce procédé, la réaction de pipérazine anhydre avec de la 4-amino-2-méthyl-10H-thiéno[2.3-b]-[1.5]benzodiazépine ou son sel d'addition d'acide inorganique est réalisée dans de la pipérazine fondue, en l'absence de solvant.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2006</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20060526&DB=EPODOC&CC=WO&NR=2006053870A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20060526&DB=EPODOC&CC=WO&NR=2006053870A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MAJKA, ZBIGNIEW</creatorcontrib><creatorcontrib>STAWINSKI, TOMASZ</creatorcontrib><creatorcontrib>RECHNIO, JUSTYNA</creatorcontrib><title>A PROCESS FOR THE PREPARATION OF N-DEMETHYLOLANZAPINE</title><description>The invention relates to the process for the preparation of N- demethylolanzapine and the use of N-demethylolanzapine obtained by the process for the preparation of antipsychotic medicament olanzapine. According to the process of the invention the reaction of an- hydrous piperazine with 4-amino-2-methyl-10H-thieno[2.3-b]- [1.5]benzodiazepine or its inorganic acid addition salt is carried out in molten piperazine, in the absence of a solvent.
L'invention concerne le procédé de préparation de N-déméthylolanzapine, ainsi que l'utilisation de la N-déméthylolanzapine obtenue par ce procédé pour préparer un médicament antipsychotique, l'olanzapine. Selon ce procédé, la réaction de pipérazine anhydre avec de la 4-amino-2-méthyl-10H-thiéno[2.3-b]-[1.5]benzodiazépine ou son sel d'addition d'acide inorganique est réalisée dans de la pipérazine fondue, en l'absence de solvant.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2006</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDB1VAgI8nd2DQ5WcPMPUgjxcAXyXQMcgxxDPP39FPzdFPx0XVx9XUM8In38fRz9ohwDPP1ceRhY0xJzilN5oTQ3g7Kba4izh25qQX58anFBYnJqXmpJfLi_kYGBmYGpsYW5gaOhMXGqAIW9KJQ</recordid><startdate>20060526</startdate><enddate>20060526</enddate><creator>MAJKA, ZBIGNIEW</creator><creator>STAWINSKI, TOMASZ</creator><creator>RECHNIO, JUSTYNA</creator><scope>EVB</scope></search><sort><creationdate>20060526</creationdate><title>A PROCESS FOR THE PREPARATION OF N-DEMETHYLOLANZAPINE</title><author>MAJKA, ZBIGNIEW ; STAWINSKI, TOMASZ ; RECHNIO, JUSTYNA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2006053870A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2006</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>MAJKA, ZBIGNIEW</creatorcontrib><creatorcontrib>STAWINSKI, TOMASZ</creatorcontrib><creatorcontrib>RECHNIO, JUSTYNA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MAJKA, ZBIGNIEW</au><au>STAWINSKI, TOMASZ</au><au>RECHNIO, JUSTYNA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>A PROCESS FOR THE PREPARATION OF N-DEMETHYLOLANZAPINE</title><date>2006-05-26</date><risdate>2006</risdate><abstract>The invention relates to the process for the preparation of N- demethylolanzapine and the use of N-demethylolanzapine obtained by the process for the preparation of antipsychotic medicament olanzapine. According to the process of the invention the reaction of an- hydrous piperazine with 4-amino-2-methyl-10H-thieno[2.3-b]- [1.5]benzodiazepine or its inorganic acid addition salt is carried out in molten piperazine, in the absence of a solvent.
L'invention concerne le procédé de préparation de N-déméthylolanzapine, ainsi que l'utilisation de la N-déméthylolanzapine obtenue par ce procédé pour préparer un médicament antipsychotique, l'olanzapine. Selon ce procédé, la réaction de pipérazine anhydre avec de la 4-amino-2-méthyl-10H-thiéno[2.3-b]-[1.5]benzodiazépine ou son sel d'addition d'acide inorganique est réalisée dans de la pipérazine fondue, en l'absence de solvant.</abstract><oa>free_for_read</oa></addata></record> |
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| title | A PROCESS FOR THE PREPARATION OF N-DEMETHYLOLANZAPINE |
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