INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS

The invention relates to compounds of the Formula (1) and to pharmaceutically acceptable salts and solvates thereof, wherein A, X2, X4, X5 and X1 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and t...

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Bibliographische Detailangaben
Hauptverfasser:	WALLER, CHRIS, L, SAMBROOK SMITH, COLIN PETER, COLLINGTON, ERIC, WILLIAM, BORZILLO, GARY, V, SADIQ, SHAZIA, BLOXHAM, JASON, WYNNE, GRAHAM, M
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to compounds of the Formula (1) and to pharmaceutically acceptable salts and solvates thereof, wherein A, X2, X4, X5 and X1 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of Formula (1). The compounds act as integrin antagonists. La présente invention concerne des composés représentés par la formule (I) ainsi que leurs sels et leurs solvates pharmaceutiquement acceptables; dans la formule, A, X2, X4, X5 et X1 étant tels que définis. Cette invention se rapporte également à des méthodes de traitement de la croissance cellulaire anormale chez les mammifères par administration des composés de formule (I), ainsi qu'à des compositions pharmaceutiques qui permettent de traiter de tels troubles et qui renferment les composés de formule (I).