EXTENDED TREATMENT OF TUMORS THROUGH VESSEL OCCLUSION WITH LIGHT ACTIVATED DRUGS

Methods of treating diseases of a subject through selective occlusion of blood vessels. The methods include identifying and/or mapping the blood vessels supplying nutrients to the diseased or unwanted tissue, delivering an appropriate dose of an occlusion-forming photosensitizer to the subject, and...

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Bibliographische Detailangaben
Hauptverfasser: WINSHIP, MYRON, JAY, XU, HONGXIA, MAHONEY, PAULA, A, CROUSE, MICHAEL, ALAN, LIANG, YAN
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:Methods of treating diseases of a subject through selective occlusion of blood vessels. The methods include identifying and/or mapping the blood vessels supplying nutrients to the diseased or unwanted tissue, delivering an appropriate dose of an occlusion-forming photosensitizer to the subject, and exciting the photosensitizer with sufficient light irradiation in the vicinity of the blood vessels to cause vessel occlusion. The vessel occlusion cuts off nutrient supply to the diseased or unwanted tissue resulting in cell death of that tissue and any other tissue served by the occluded vessels. Cette invention concerne des procédés pour traiter les maladies d'un patient par l'occlusion sélective des vaisseaux sanguins. Ces procédés comprennent l'identification et/ou la cartographie des vaisseaux sanguins alimentant le tissu malade ou indésirable en substances nutritives, l'administration au patient d'une dose appropriée d'un photosensibilisant provoquant l'occlusion, et l'excitation du photosensibilisant avec suffisamment de lumière à proximité des vaisseaux sanguins pour provoquer l'occlusion de ces vaisseaux. L'occlusion des vaisseaux interrompt l'alimentation du tissu malade ou indésirable, aboutissant à la mort cellulaire de ce tissu et de tout autre tissu alimenté par les vaisseaux occlus.