USE OF PURIFIED DONEPEZIL MALEATE FOR PREPARING PHARMACEUTICALLY PURE AMORPHOUS DONEPEZIL HYDROCHLORIDE

USE OF PURIFIED DONEPEZIL MALEATE FOR PREPARING PHARMACEUTICALLY PURE AMORPHOUS DONEPEZIL HYDROCHLORIDE

The present invention provides a crystalline donepezil maleate, which is used as an intermediate in the preparation of donepezil hydrochloride. Also provided are novel processes for producing same in substantially pure form and a process for producing pharmaceutically pure amorphous donepezil hydroc...

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Bibliographische Detailangaben
Hauptverfasser: ALNABARI, MOHAMMED, BENTOLILA, MOSHE, KASPI, JOSEPH, SALMAN, ADA, KURLAT, ORNA, SHOOKRUN, MOTY, SHIFFER, MEITAL, BRAND, MICHAEL, ARAD, ODED, ZELIKOVITCH, LIOR, GRIBUN, IRINA
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention provides a crystalline donepezil maleate, which is used as an intermediate in the preparation of donepezil hydrochloride. Also provided are novel processes for producing same in substantially pure form and a process for producing pharmaceutically pure amorphous donepezil hydrochloride therefrom. La présente invention concerne un maléate de donépézil cristallin qui est utilisé comme intermédiaire dans la préparation d'hydrochlorure de donépézil. Cette invention concerne également des nouveaux procédés de production de celui-ci dans une forme substantiellement pure et un procédé de production d'hydrochlorure de donépézyl amorphe pharmaceutiquement pur.