NUCLEOSIDE-LIPID CONJUGATES, THEIR METHOD OF PREPARATION AND USES THEREOF

The invention provides methods for synthesizing nucleoside-lipid conjugates having varying fatty acid and alkyl chain lengths with or without unsaturation and their use in the treatment of cancer and viral diseases. More particularly, the invention provides methods for preparing gemcitabine-cardioli...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	AHMAD, MOGHIS, U, KHAN, ABDUL, R, ALI, SHOUKATH, M, AHMAD, IMRAN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Beschreibung
Zusammenfassung:	The invention provides methods for synthesizing nucleoside-lipid conjugates having varying fatty acid and alkyl chain lengths with or without unsaturation and their use in the treatment of cancer and viral diseases. More particularly, the invention provides methods for preparing gemcitabine-cardiolipin conjugates, and analogues thereof, cytarabine-cardiolipin conjugates, and analogues thereof. Additionally, the methods of the invention comprise administering a compound of invention as prodrug or a pharmaceutical preparation to combat mammalian diseases, preferably cancer, viral infections and bone disorders. L'invention concerne des procédés pour synthétiser des conjugués nucléoside-lipide comportant des chaînes d'acides gras et des chaînes alkyle de longueurs variables, insaturées ou non, ainsi que l'utilisation de ces conjugués pour traiter le cancer et des maladies virales. Cette invention se rapporte en particulier à des procédés pour préparer des conjugués gemcitabine-cardiolipine et leurs analogues, ainsi que des conjugués cytarabine-cardiolipine et leurs analogues. En outre, les procédés selon l'invention consistent à administrer un composé selon l'invention en tant que promédicament ou préparation pharmaceutique pour combattre des maladies affectant les mammifères, de préférence le cancer, des infections virales, et des troubles osseux.