TRIAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATION

This invention is directed generally to triazolopyridine compounds that generally inhibit p38 kinase, TNF, and/or cyclooxygenase activity. Such triazolopyridine include compounds generally corresponding in structure to the following formula (I): Wherein R1, R2, R3, R4, and R5are as defined in this s...

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Bibliographische Detailangaben
Hauptverfasser:	XING, LI, BALDUS, JOHN, EDWARD, JEROME, KEVIN, DEWAYNE, SELNESS, SHAUN, RAJ, RUCKER, PAUL, V
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention is directed generally to triazolopyridine compounds that generally inhibit p38 kinase, TNF, and/or cyclooxygenase activity. Such triazolopyridine include compounds generally corresponding in structure to the following formula (I): Wherein R1, R2, R3, R4, and R5are as defined in this specification. This invention also is directed to compositions of such triazolopyridines (particularly pharmaceutical compositions), intermediates for the syntheses of such triazolopyridines, methods for making such triazolopyridines, and methods for treating (including preventing) conditions (typically pathological conditions) associated with p38 kinase activity, TNF activity, and/or cyclooxygenase-2 activity. L'invention concerne, de façon générale, des composés de triazolopyridine qui inhibent généralement l'activité de la p38 kinase, de TNF, et/ou de la cyclo-oxygénase. De telles triazolopyridines comprennent des composés dont la structure correspond généralement à la formule (I), dans laquelle R1, R2, R3, R4, et R5 sont tels que définis dans la description. L'invention concerne également des compositions de telles triazolopyridines (en particulier, des compositions pharmaceutiques), des produits intermédiaires servant aux synthèses de telles triazolopyridines, des procédés de fabrication desdites triazolopyridines, ainsi que des procédés de traitement (y compris de prévention) d'états (spécifiquement, d'états pathologiques) associés à l'activité de la p38 kinase, de l'activité de TNF et/ou de l'activité de la cyclo-oxygénase 2.