ARYL-AMINO SUBSTITUTED PYRROLOPYRIMIDINE MULTI-KINASE INHIBITING COMPOUNDS

Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mekl, PDK-1, GSK3ß, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-lR, Ron, Ret, and KDR kinases in animal...

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Bibliographische Detailangaben
Hauptverfasser:	KITCHIN, JOHN, SABA, IMAAD, FOREMAN, KENNETH, TAVARES, PAULA, DAWSON, GRAHAM, PEGG, NEIL, ANTHONY, PANICKER, BIJOY, WENG, QINGHUA, FELIX, MA, LIFU, SHADIQ, SHAZIA, COX, MATTHEW, STEINIG, ARNO, G, GATTRELL, WILLIAM, WILKES, ROBIN, BARBA, OSCAR, AHMED, SALEH, LI, AN-HU, SMYTH, DON, BLOXHAM, JASON, STOLZ, KATHRYN, DONG, HANQING, SMITH, COLIN, PETER, SAMBROOK
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mekl, PDK-1, GSK3ß, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-lR, Ron, Ret, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer. La présente invention a trait à des composés de formule (I), ou leurs stéréoisomères ou sels pharmaceutiquement acceptables, inhibiteurs d'au moins deux parmi les kinases Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mekl, PDK-1, GSK3ß, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-lR, Ron, Ret, et KDR chez des animaux, comprenant les humains, pour le traitement et/ou la prévention de diverses maladies et conditions telles que le cancer.