METHODS OF USING ZC1 AND ZC3 KINASE SUBSTRATE PHOSPHORYLATION AS BIOMARKERS

The present invention provides novel biomarkers for cancer: the phosphorylation of ZC1 and/or ZC3 kinase substrates, particularly p120 catenin and Abi-1. Accordingly, the invention provides methods of determining whether a mammal is responding to a compounds that modulates ZC1 or ZC3 kinase activity...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	SUNG, VICTORIA, WRIGHT, JOCELYN, H, BLACKWOOD, ELIZABETH, MARIE, FAURE, MICHEL, PAUL
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention provides novel biomarkers for cancer: the phosphorylation of ZC1 and/or ZC3 kinase substrates, particularly p120 catenin and Abi-1. Accordingly, the invention provides methods of determining whether a mammal is responding to a compounds that modulates ZC1 or ZC3 kinase activity, and methods of predicting whether a mammal will respond therapeutically to a method of treating cancer by administering a modulator of ZC1 or ZC3 kinase. L'invention concerne des biomarqueurs pour le cancer résultant de la phosphorylation de substrat de kinase ZC1 et ZC3, en particulier caténine p120 et Abi-1. On décrit des procédés permettant de déterminer si un composé module l'activité de kinase considérée, des procédés permettant de déterminer si un mammifère réagit à un composé de ce type, et des procédés permettant de prévoir si un mammifère réagira du point de vue thérapeutique à une technique de traitement du cancer par administration de modulateur correspondant.