USE OF MDCK CELL LINE TO PREDICT CORNEAL PENETRATION OF DRUGS

A new method of evaluating the ability of drug molecules to penetrate the cornea is described. The permeation rate of the drug molecules in MDCK cells is utilized to predict the ability of the molecules to penetrate the cornea. The method is useful for in vitro screening of potential new ophthalmic...

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Bibliographische Detailangaben
Hauptverfasser:	OWEN, GEOFFREY, ROBERT, RUSINKO, ANDREW, HELLBERG, MARK, R, MAY, JESSE, ALBERT
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CALCULATING CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPUTING CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES COUNTING ELECTRIC DIGITAL DATA PROCESSING ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	A new method of evaluating the ability of drug molecules to penetrate the cornea is described. The permeation rate of the drug molecules in MDCK cells is utilized to predict the ability of the molecules to penetrate the cornea. The method is useful for in vitro screening of potential new ophthalmic drugs, as well as in the design of new drug molecules for topical ocular administration. L'invention concerne un nouveau procédé d'évaluation de la capacité des molécules d'un médicament de pénétrer dans la cornée. La vitesse de perméation des cellules MDCK aux molécules d'un médicament est utilisée pour prédire la capacité des molécules de pénétrer dans la cornée. Le procédé est utile dans le criblage in vitro de nouveaux médicaments ophtalmologiques potentiels ainsi que dans la conception de nouvelles molécules de médicaments dans l'administration oculaire topique.