COMPOUNDS HAVING MORPHOLINYL AND PIPERIDINYL GROUPS FOR USE AS GLYT1 INHIBITORS

The invention provides a compound of formula (I) or a salt or solvate thereof: (I); wherein R, R , R , R , R , R , R , R , R , n and Ar are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological an...

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Bibliographische Detailangaben
Hauptverfasser:	NASH, DAVID, JOHN, BRANCH, CLIVE, LESLIE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The invention provides a compound of formula (I) or a salt or solvate thereof: (I); wherein R, R , R , R , R , R , R , R , R , n and Ar are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia. L'invention concerne un composé de formule (I) ou un sel ou un solvate de ce dernier. Dans ladite formule (I), R, R , R , R , R , R , R , R , R , n et Ar sont tels que définis dans la description. L'invention concerne également des utilisations desdits composés. Lesdits composés inhibent les transporteurs de GlyT1 et sont utiles dans le traitement de certains troubles neurologiques et neuropsychiatriques, notamment de la schizophrénie.