METHOD FOR PRODUCING PURINE NUCLEOSIDES AND NUCLEOTIDES BY FERMENTATION USING BACTERIUM BELONGING TO THE GENUS BACILLUS OR ESCHERICHIA

METHOD FOR PRODUCING PURINE NUCLEOSIDES AND NUCLEOTIDES BY FERMENTATION USING BACTERIUM BELONGING TO THE GENUS BACILLUS OR ESCHERICHIA

Methods for producing purine base analogues, purine nucleosides, and purine nucleotides, such as inosine and 5'-inosinic acid are provided which include using a bacterium belonging to the genus Bacillus or to the genus Escherichia wherein the purine productivity of said bacterium is enhanced by...

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Bibliographische Detailangaben
Hauptverfasser: KUTUKOVA, EKATERINA, ALEKSANDROVNA, LIVSHITS, VITALY, ARKADIEVICH, KOZLOV, YURI, IVANOVICH, GRONSKY, SERGEY, VIKTOROVICH, ZAKATAEVA, NATALIA, PAVLOVNA, NOVIKOVA, ANNA, EVGENIEVNA
Format: Patent
Sprache:eng ; fre
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:Methods for producing purine base analogues, purine nucleosides, and purine nucleotides, such as inosine and 5'-inosinic acid are provided which include using a bacterium belonging to the genus Bacillus or to the genus Escherichia wherein the purine productivity of said bacterium is enhanced by increasing an activity of the YdhL protein. Also disclosed is the amino acid sequence of the YdhL protein from Bacillus amyloliquefaciens and the gene encoding it. Des procédés destinés à produire des antipurines de base, des nucleosides de purine et des nucléotides de purine, tels que l'inosine et l'acide 5'-inosinique sont prévus, lesquels comprennent l'utilisation d'une bactérie appartenant au genus Bacillus ou au genus Escherichia dans lesquels la productivité en purine de ladite bactérie est améliorée en augmentant l'activité de la protéine YdhL. Il est également décrit la séquence d'acide aminé de la protéine YdhL à partir du Bacillus amyloliquefaciens et du gène qui le code.