NOVEL TRICYCLIC COMPOUNDS AND RELATED METHODS OF TREATMENT
The invention provides novel lipid soluble forms of tricyclic antineoplastic compounds. These forms include salts, co-crystals, and solvates of the tricyclic antineoplastic compounds. The invention also provides novel pharmaceutical compositions comprising these novel lipid soluble forms and related...
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| Format: | Patent |
| Sprache: | eng ; fre |
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| Zusammenfassung: | The invention provides novel lipid soluble forms of tricyclic antineoplastic compounds. These forms include salts, co-crystals, and solvates of the tricyclic antineoplastic compounds. The invention also provides novel pharmaceutical compositions comprising these novel lipid soluble forms and related methods of treatment. Compositions and methods of the invention are useful in the treatment of neoplasms, including MRP-1-related resistant neoplasms.
Cette invention concerne de nouvelles formes solubles lipides de composés antinéoplasiques tricycliques. Ces formes comprennent des sels, des co-cristaux et des solvates de ces composés antinéoplasiques tricycliques. Cette invention concerne également de nouvelles compositions pharmaceutiques renfermant ces nouvelles formes solubles lipides ainsi que les méthodes de traitement correspondantes. Les compositions et les méthodes de cette invention sont utilisées dans le traitement de néoplasmes, y compris de néoplasmes résistants associés à MRP-1. |
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