METHODS FOR THE INDENTIFICATION OF INHIBITORS OF HISTIDINOL DEHYDROGENASE AS ANTIBIOTICS

The present inventors have discovered that a histidinol dehydrogenase (HIS4) is essential for normal fungal pathogenicity. Specifically, the inhibition of HIS4 gene expression in Magnaportha grisea severely reduces the pathogenicity of the fungus. Thus, HIS4 is useful as a target for the identificat...

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Hauptverfasser:	DEZWAAN, TODD, M, MAHANTY, SANJOY, K, TANZER, MATTHEW, M, HEINIGER, RYAN, W, PAN, HUAQIN, MONTENEGROAMORRO, MARIA, VICTORIA, DARVEAUX, BLAISE, A, LO, SZEUNG, C, TARPEY, REX, ADACHI, KIICHI, SHUSTER, JEFFREY, R, HAMER, LISBETH, FRANK, SHERYL, A, COVINGTON, AMY, S
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present inventors have discovered that a histidinol dehydrogenase (HIS4) is essential for normal fungal pathogenicity. Specifically, the inhibition of HIS4 gene expression in Magnaportha grisea severely reduces the pathogenicity of the fungus. Thus, HIS4 is useful as a target for the identification of antibiotics, preferably fungicides. Accordingly, the present invention provides methods for the identification of compounds that inhibit HIS4 expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably fungicides. Les inventeurs ont découvert que l'histidinol deshydrogénase (HIS4) est crucial pour la pathogénicité fongique normale. Plus particulièrement, l'inhibition de l'expression de gène HIS4 dans Magnaportha grisea réduit sensiblement la pathogénicité du champignon. Le HIS4 est ainsi utile en tant que cible destinée à l'identification d'antibiotiques, de préférence de fongicides. De cette manière, la présente invention propose des procédés pour l'identification des composés pour inhiber l'expression ou l'activité de HIS4. Les procédés de l'invention sont utiles pour l'identification des antibiotiques et notamment des fongicides.