CANCER TREATMENT AND ASSAYS FOR DETERMINING RESISTANCE TO PLATINUM-BASED CHEMOTHERAPEUTIC AGENT

Described is a method to predict response of tumour cells to in vivo treatment with a platinum-based chemotherapeutíc agent, the method based on the determination of the expression of one or more of the genes encoding BCRP protein, wherein enhanced expression of said gene correlates with enhanced re...

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Bibliographische Detailangaben
Hauptverfasser:	JOHNSTON, PATRICK, GERARD, LONGLEY, DANIEL
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Described is a method to predict response of tumour cells to in vivo treatment with a platinum-based chemotherapeutíc agent, the method based on the determination of the expression of one or more of the genes encoding BCRP protein, wherein enhanced expression of said gene correlates with enhanced resistance to the chemotherapeutic agent. Also described are methods of sensitising cancer cells, particularly colorectal cancer cells to treatment. L'invention concerne une méthode permettant de prédire une réaction de cellules tumorales à un traitement in vivo, qui fait intervenir un agent chimiothérapique à base de platine. Cette méthode est fondée sur la détermination de l'expression d'un ou de plusieurs gènes codant pour une protéine BCRP, l'expression accrue du ou desdits gènes étant corrélée à une résistance accrue à l'agent chimiothérapique. L'invention concerne également des méthodes de sensibilisation de cellules cancéreuses, en particulier de cellules de cancer colorectal à un traitement.