ONCOLYTIC ADENOVIRUS ARMED WITH THERAPEUTIC GENES

The present invention involves compositions and methods for treating cancer using a mutant adenovirus comprising a polynucleotide encoding a therapeutic polypeptide that is targeted to cells with a mutant retinoblastoma pathway. The mutant adenovirus is able to kill the tumor cells without harming c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	LANG, FREDERICK, F., JR, YUNG, W., K., ALFRED, CONRAD, CHARLES, A, FUEYO, JUAN, GOMEZ-MANZANO, CANDELARIA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention involves compositions and methods for treating cancer using a mutant adenovirus comprising a polynucleotide encoding a therapeutic polypeptide that is targeted to cells with a mutant retinoblastoma pathway. The mutant adenovirus is able to kill the tumor cells without harming cells with a wild type retinoblastoma pathway. L'invention concerne des compositions et des procédés pour traiter le cancer au moyen d'un adénovirus mutant comprenant un polynucléotide codant un polypeptide thérapeutique, lequel est ciblé sur des cellules au moyen d'une voie du rétinoblastome mutant. Ledit adénovirus mutant est capable de tuer des cellules tumorales sans endommager les cellules au moyen d'une voie du rétinoblastome de type sauvage.