DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH GLYCOGEN SYNTHASE KINASE 3 BETA (GSK3B)

The invention provides a human GSK3B which is associated with cardiovascular diseases, cancer, metabolic diseases, hematological diseases, inflammation, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	GOLZ, STEFAN, GEERTS, ANDREAS, BRUEGGEMEIER, ULF, WEINGAERTNER, BERNHARD
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The invention provides a human GSK3B which is associated with cardiovascular diseases, cancer, metabolic diseases, hematological diseases, inflammation, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, metabolic diseases, hematological diseases, inflammation, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GSK3B as well as pharmaceutical compositions comprising such compounds. L'invention concerne une GSK3B humaine qui est associée à des maladies cardiovasculaires, à des cancers, à des maladies métaboliques, à des maladies hématologiques, aux inflammations, à des maladies respiratoires, à des maladies neurologiques et à des maladies urologiques. L'invention concerne également des méthodes permettant l'identification de composés pouvant servir au traitement ou à la prévention des maladies cardio-vasculaires, des cancers, des maladies métaboliques, des maladies hématologiques, des inflammations, des maladies respiratoires, des maladies neurologiques et des maladies urologiques. L'invention concerne en outre des composés qui se lient avec GSK3B et/ou activent ou inhibent l'activité de celle-ci, ainsi que des compositions pharmaceutiques contenant ces composés.