PEPTIDE MIMOTOPES OF MYCOBACTERIAL MANNOSYLATED LIPOGLYCANS AND USES THEREOF

The present invention relates to the identification of antigenic and immunogenic peptide-based mimicry of mannose-containing cell-wall compounds characterizing mycobacterial infectious agents, such as Mycobacterium tuberculosis. Thus, the present invention provides amino acid molecules which are mim...

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Bibliographische Detailangaben
Hauptverfasser:	GERSHONI, JONATHAN, BARENHOLZ, AYELET, BERCOVIER, HERVE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to the identification of antigenic and immunogenic peptide-based mimicry of mannose-containing cell-wall compounds characterizing mycobacterial infectious agents, such as Mycobacterium tuberculosis. Thus, the present invention provides amino acid molecules which are mimotopes of mannosylated lipoglycans, such as lipoarabinomannan (ManLAM), comprising at least one of the following characteristics: (a) being capable of binding to ManLAM binding antibodies; (b) being capable of eliciting production of ManLAM binding antibodies. The amino acid of the invention is used in a diagnostic method for diagnosing mycobacterial infections and in a method of vaccinating subject against such infections. Accordingly, the invention also provides a diagnostic kit and a vaccine for the executing the aforementioned methods. L'invention porte sur l'identification du mimétisme peptidique antigénique et immunogénique des composés pariétaux contenant du mannose, caractérisant les agents infectieux mycobactériens tels que Mycobacterium tuberculosis. L'invention concerne de ce fait des molécules d'acides aminés qui sont des mimotopes de lipoglycanes mannosylés tels que le lipoarabinomannane (ManLAM), et présentant au moins une des caractéristiques suivantes: (a) capacité de se lier aux anticorps de fixation du ManLAM; (b) capacité de déclencher la production d'anticorps de fixation du ManLAM. L'acide aminé décrit est utilisé dans une méthode diagnostique permettant de diagnostiquer les infections mycobactériennes et une méthode permettant de vacciner un sujet contre de telles infections. L'invention concerne également une trousse de diagnostic et un vaccin permettant la mise en oeuvre desdites méthodes.