A COUPLING DEVICE ENABLED BY MECHANICAL CONTINUITY OF CELLULAR SCAFFOLDING ACROSS TISSUE BOUNDARIES

A device and method for achieving load-bearing living-tissue-to-living-tissue coupling comprises a myriad of fine fibers (12) extending directly from within the substance of one tissue to within the substance of the other tissue. Fibers (12) are similar in cross-sectional area to, or smaller than, h...

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Bibliographische Detailangaben
Hauptverfasser:	BYRNE, MARK, T, MELVIN, DAVID, BOYD, MELVIN, ALAN, J
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DIAGNOSIS DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE IDENTIFICATION MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL SURGERY
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Beschreibung
Zusammenfassung:	A device and method for achieving load-bearing living-tissue-to-living-tissue coupling comprises a myriad of fine fibers (12) extending directly from within the substance of one tissue to within the substance of the other tissue. Fibers (12) are similar in cross-sectional area to, or smaller than, host tissue cells. This enables fibers (12) to provide a scaffolding into which proliferating cells of each tissue may grow to form a collagenous matrix enveloping individual fibers and transferring mechanical loads between each tissue's extracellular matrix and the fibers. Also taught are devices and methods (1) for delivering bundles of independent fibers into soft or hard tissue, (2) for transiently reducing tissue drag during insertion, (3) for temporarily stabilizing position during tissue ingrowth, and (4) for spatial distribution of fiber bending stress in the event of a hard tissue. L'invention concerne un dispositif et un procédé d'obtention d'un couplage tissu vivant à tissu vivant supportant la charge comprenant une myriade de fines fibres s'étendant directement depuis l'intérieur de la substance d'un tissu jusqu'à l'intérieur de la substance de l'autre tissu. Les fibres ont une surface de section transversale similaire, ou inférieure à celle des cellules tissulaires hôtes. Ceci permet aux fibres de former un échafaudage sur lequel les cellules proliférantes de chaque tissu peuvent se développer pour former une matrice collagène enveloppant les fibres individuelles et transférant les charges mécaniques entre chaque matrice extra-cellulaire des tissus et les fibres. L'invention concerne également des dispositifs et des procédés (1) d'apport de faisceaux de fibres indépendantes dans les tissus mous ou durs, (2) de réduction transitoire de l'étirement des tissus pendant l'insertion, (3) de stabilisation temporaire de la position pendant la croissance interne des tissus, et (4) de répartition spatiale de la contrainte de pliage des fibres dans le cas d'un tissu dur.