ANTIBODY LINKED CATIONIC EMULSIONS AS DRUG DELIVERY SYSTEM

ANTIBODY LINKED CATIONIC EMULSIONS AS DRUG DELIVERY SYSTEM

A combination product comprising a positive oil in water emulsion wherein said emulsion comprises a compound presenting free NH2 groups, at its natural state, at the oil-water interface, and an antibody, wherein said compound is linked to said antibody by a heterobifunctional linker, linking said NH...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LAMBERT, GREGORY, YANG, SHICHENG, GURSOY, NESLIHAN, BENITA, SIMON, NASSAR, TAHER, KADOUCHE, JEAN, RAZAFINDRATSITA, ALAIN, GOLDSTEIN, DANNY, KEREN-HAYESOD, SADER, OLA
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:A combination product comprising a positive oil in water emulsion wherein said emulsion comprises a compound presenting free NH2 groups, at its natural state, at the oil-water interface, and an antibody, wherein said compound is linked to said antibody by a heterobifunctional linker, linking said NH2 groups to SH groups on the antibody hinge region. L'invention porte sur un produit de combinaison comprenant une émulsion huile dans eau positive, ladite émulsion comprenant un composé qui présente, à l'état naturel, des groupes NH2 libres à l'interface huile-eau, et un anticorps, lequel composé est lié à l'anticorps précité par un lieur hétérobifonctionnel qui lie les groupes NH2 précités aux groupes SH sur la région charnière de l'anticorps.