METHODS OF USE FOR SECRETED FRIZZLED-RELATED PROTEIN 3 (SFRP-3) IN THE PREVENTION AND TREATMENT OF DISEASE

Compositions containing sFRP-3 polypeptides, polynucleotides, and modulators thereof, such as antibodies thereto, are provided. Such compositions are useful for the treatment, prevention, and diagnosis of diseases. Such diseases include immune and proliferative diseases. Methods for utilizing these...

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Hauptverfasser:	COLLINS, AMY, L., TSUI, LIN, HAISHAN, PIERCE, KRISTEN, BEAURANG, PIERRE, ALVARO, ZHANG, HONGBING, WILLIAMS, LEWIS, THOMAS, CHU, KETING, WANG, YAN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING
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Beschreibung
Zusammenfassung:	Compositions containing sFRP-3 polypeptides, polynucleotides, and modulators thereof, such as antibodies thereto, are provided. Such compositions are useful for the treatment, prevention, and diagnosis of diseases. Such diseases include immune and proliferative diseases. Methods for utilizing these polypeptides, polynucleotides, and modulators aredisclosed; they include methods for treating proliferative, inflammatory, and bone and cartilage diseases. L'invention concerne des compositions contenant des polypeptides, polynucléotides sFRP-3 (secreted frizzled related protein) et leurs modulateurs, tels que leurs anticorps. De telles compositions sont utiles pour le traitement, la prévention et le diagnostic de maladies. De telles maladies comportent les maladies immunitaires et proliférantes. L'invention concerne également des procédés d'utilisation de ces polypeptides, polynucléotides et modulateurs, y compris des procédés de traitement des maladies proliférantes, inflammatoires et des maladies des os et du cartilage.