CHRYSOGENAZINE OBTAINED FROM FUNGUS PENICILLIUM CHRYSOGENUM HAVING ANTIBACTERIAL ACTIVITY

The present invention relates a novel compound, chrysogenazine containing both indole and diketopiperazine ring systems, isolated from the chloroform fraction of the fermentation broth of Penicillium chrysogenum and the gross structure of the compound was elucidated by a detailed analysis of spectro...

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Bibliographische Detailangaben
Hauptverfasser:	RODRIGUES, ELY, NAIK, CHANDRAKANT, GOVIND, DEVI, PRABHA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates a novel compound, chrysogenazine containing both indole and diketopiperazine ring systems, isolated from the chloroform fraction of the fermentation broth of Penicillium chrysogenum and the gross structure of the compound was elucidated by a detailed analysis of spectroscopic data (IR, NMR, MS), in addition, this invention also assesses the biological activity of the compound which reveals its antibacterial activity against the human pathogen, Vibrio cholerae, demonstrated by the disc diffusion assay. La présente invention porte sur un nouveau composé, la chrysogenazine contenant à la fois des systèmes cycliques indole et dicétopipérazine, isolé du fragment de chloroforme du bouillon de fermentation de Penicillium chrysogenum et la structure brute du composé a été élucidé par une analyse détaillée de données spectroscopiques (IR, NMR, MS). L'invention permet également d'évaluer l'activité biologique du composé qui se révèle être une activité anti-bactérienne dirigée contre le pathogène humain Vibrio cholerae au moyen de l'essai de diffusion de disque.