ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS

This invention provides cholesterol absorption inhibitors of formula (I), and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventin atherosclerosis and atherosclerotic di...

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Bibliographische Detailangaben
Hauptverfasser:	VON LANGEN, DEREK, OGAWA, ANTHONY, GOULET, MARK, T, UJJAINWALLA, FEROZE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	This invention provides cholesterol absorption inhibitors of formula (I), and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventin atherosclerosis and atherosclerotic disease events. L'invention porte sur des inhibiteurs d'absorption du cholestérol de formule (I) et sur leurs sels et esters pharmacocompatibles. Lesdits composés s'avèrent utiles pour abaisser les niveaux plasmiques des cholestérols, et en particulier du cholestérol LDL, et traiter et prévenir l'athérosclérose et les troubles athérosclérotiques.