CYTOKINE INVOLVED IN EPITHELIAL-MESENCHYMAL TRANSITION

The functional characterization of ILEI to be a cytokine involved in epithelial/mesenchymal transition and the identification of biologically active ILEI provides the basis for generating ILEI inhibitors, in particular anti-ILEI antibodies, that are useful in the therapy of cancer, fibrosis and COPD...

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Hauptverfasser:	GRUENERT, STEFAN, WAERNER, THOMAS, BEUG, HARTMUT, KRAUT, NORBERT, JECHLINGER, MARTIN, TAMIR, IDO, HEIDER, KARL-HEINZ, ZOEPHEL, ANDREAS, JUNG, BIRGIT, AHORN, HORST, WEITH, ANDREAS, SEITHER, PETER, KONOPITZKY, RENATE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Zusammenfassung:	The functional characterization of ILEI to be a cytokine involved in epithelial/mesenchymal transition and the identification of biologically active ILEI provides the basis for generating ILEI inhibitors, in particular anti-ILEI antibodies, that are useful in the therapy of cancer, fibrosis and COPD. La caractérisation fonctionnelle d'ILEI pour une cytokine impliquée dans la transition épithéliale / mésenchymale et l'identification d'ILEI présentant une activité biologique fournit une base pour générer des inhibiteurs d'ILEI, en particulier d'anticorps anti-ILEI, qui sont utiles dans la thérapie du cancer, de la fibrose et de BPCO.