CHELATE BASED SCAFFOLDS IN TUMOR TARGETING

This invention relates to novel complexes that can be used to target tumor cells. The complexes include a ligand that can bind metal ions including radioactive lanthanide ions. The complexes can mimic alphavbeta3 integrin receptor antagonists and deliver the complexed radioactive metals to the tumor...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	SUHR, ROBERT, G, GARLICH, JOSEPH, R, PATTERSON, MARY
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	This invention relates to novel complexes that can be used to target tumor cells. The complexes include a ligand that can bind metal ions including radioactive lanthanide ions. The complexes can mimic alphavbeta3 integrin receptor antagonists and deliver the complexed radioactive metals to the tumor cells. L'invention concerne des nouveaux complexes pouvant être utilisés pour le ciblage de cellules tumorales. Ces complexes comprennent un ligand qui peut se lier à des ions métalliques, notamment à des ions lanthanide radioactifs. Lesdits complexes peuvent imiter des antagonistes du récepteur intégrine alpha v beta 3 et distribuer les métaux radioactifs complexes aux cellules tumorales.