CELLS, COMPOSITIONS AND METHODS FOR REPRESSING B CELL AUTOANTIBODY SECRETION AND FOR TREATING AUTOIMMUNE DISEASE

The invention provides isolated regulatory immune cells as well as cell cultures and conditioned media derived therefrom. Also provided are methods of repressing B cell autoantibody production and/or secretion and methods of treating autoimmune disease. Further provided are methods of diagnosing whe...

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Hauptverfasser:	RUTAN, JENNIFER, A, KILMON, MICHELLE, VILEN, BARBARA, J
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides isolated regulatory immune cells as well as cell cultures and conditioned media derived therefrom. Also provided are methods of repressing B cell autoantibody production and/or secretion and methods of treating autoimmune disease. Further provided are methods of diagnosing whether a mammalian subject has a defect in regulatory cell mediated repression of autoantibody secretion by B cells. Cette invention ce rapporte à des cellules immunes régulatrices isolées, ainsi qu'à des cultures cellulaires et des milieux conditionnés dérivés de celles-ci. Cette invention concerne également des procédés pour réprimer la production et/ou la sécrétion d'auto-anticorps par les lymphocytes B et des procédés pour traiter les maladies auto-immunes. Cette invention concerne en outre des procédés pour diagnostiquer chez un sujet mammifère un défaut de régulation de la répression cellulo-médiée de la sécrétion d'auto-anticorps par les lymphocytes B.