4-CYCLOALKYLAMINOPYRAZOLO PYRIMIDINE NMDA/NR2B ANTAGONISTS

Compounds represented by Formula (I) or pharmaceutically acceptable salts thereof, are effective as NMDA/NR2B antagonists useful for treating neurological conditions such as, for example, pain, Parkinson's disease, Alzheimer's disease, epilepsy, depression, anxiety, ischemic brain injury i...

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Bibliographische Detailangaben
Hauptverfasser:	YOUNG, STEVEN, D, MCCAULEY, JAMES, A, BUTCHER, JOHN, WHITTER, WILLIE, LIVERTON, NIGEL, DIECKHAUS, CHRISTINE, MUNSON, PETER, THOMPSON, WAYNE, LAYTON, MARK, E, PHILLIPS, BRIAN, T, SANDERSON, PHILIP, E, MCINTYRE, CHARLES, J
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Compounds represented by Formula (I) or pharmaceutically acceptable salts thereof, are effective as NMDA/NR2B antagonists useful for treating neurological conditions such as, for example, pain, Parkinson's disease, Alzheimer's disease, epilepsy, depression, anxiety, ischemic brain injury including stroke, and other conditions. La présente invention concerne des composés représentés par la formule (I), ou certains de leurs sels pharmaceutiquement admis. Ces produits, qui se comportent comme des antagonistes des NMDA/NR2B, conviennent particulièrement au traitement d'états neurologiques tels que la douleur, les maladies de Parkinson et d'Alzheimer, l'épilepsie, la dépression, l'anxiété, les lésions ischémiques cérébrales, y compris les attaques, et d'autres états.