ARYLSULFONAMIDOBENZYLIC COMPOUNDS

ARYLSULFONAMIDOBENZYLIC COMPOUNDS

Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment or prevention of lipid disorders, metabolic disorders and cell-proliferative diseases. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved i...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: JONES, STUART, D, JIAO, XIAN, YUN, HARRISON, MARTIN, J, KAYSER, FRANK, KOPECKY, DAVID, J
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment or prevention of lipid disorders, metabolic disorders and cell-proliferative diseases. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in cholesterol metabolism. The subject compounds are particularly useful in the treatment of obesity, diabetes, hypercholesterolemia, atherosclerosis and hypolipoproteinemia. L'invention concerne des composés, des compositions pharmaceutiques et des procédés servant à traiter ou prévenir des troubles lipidiques, des troubles métaboliques ainsi que des maladies liées à la prolifération cellulaire. Cette invention se rapporte en particulier à des composés qui modulent l'expression et/ou le fonctionnement de protéines impliquées dans le métabolisme du cholestérol. Les composés selon l'invention servent en particulier à traiter l'obésité, le diabète, l'hypercholestérolémie, l'athérosclérose et l'hypolipoproteinémie.