ERK7 AND ERK8, NOVEL DIAGNOSTIC MARKERS FOR CANCER

The present invention is directed in part to the discovery of a novel signal transduction pathway that regulates estrogen responsiveness. Human extracellular signal-regulated kinase 8 (ERK8) has been discovered by applicants to preferentially enhance the destruction of ERalpha , and loss of ERK8 is...

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Bibliographische Detailangaben
Hauptverfasser:	HENRICH, LORIN, M, SMITH, JEFFREY, A, LANNIGAN-MACARA, DEBORAH, A
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention is directed in part to the discovery of a novel signal transduction pathway that regulates estrogen responsiveness. Human extracellular signal-regulated kinase 8 (ERK8) has been discovered by applicants to preferentially enhance the destruction of ERalpha , and loss of ERK8 is correlated with breast cancer progression. Thus monitoring the expression of ERK8 can be used as a diagnostic and therapeutic indicator of cancer and cancer progression. L'invention concerne en partie la découverte d'un nouvelle voie de transduction de signal régulant la faculté de réponse d'oestrogène. On a découvert que la kinase 8 humaine à régulation de signal extracellulaire (ERK8) augmentait préférentiellement la destruction de ER alpha , et que la perte de ERK8 était en corrélation avec le développement du cancer du sein. Ainsi, le contrôle de l'expression de ERK8 peut être utilisé comme indicateur de diagnostic et comme thérapeutique du cancer et du développement du cancer.