FLUCONAZOLE CAPSULES WITH IMPROVED RELEASE

The object of the invention is to provide fluconazole containing capsules with improved active ingredient release. The in vitro dissolution as well as in vivo absorption of the fluconazole capsules according to the invention is faster and more consistent than those of commercial compositions containing fluconazole. The invention is based on the fact that granulation of fluconazole particles with an agent capable to provide hydrophilic surface, e.g. lactose, to said particles results in fast an consistent release of the active ingredient. In this way, capsules according to the invention are suitable to provide enhanced absorption of said active ingredient. La présente invention concerne des capsules contenant du fluconazole ayant une libération améliorée des substances actives. La dissolution in vitro ainsi que l'absorption in vivo des capsules de fluconazole de l'invention, sont plus rapides et plus importantes que celles des compositions contenant du fluconazole, de l'état de la technique. L'invention repose sur le fait que la granulation de particules de fluconazole avec un agent capable de doter lesdites particules d'une surface hydrophile, permet d'obtenir une libération rapide et importante de la substance active. De cette manière, les capsules de l'invention permettent d'obtenir une absorption améliorée de ladite substance active.