ADKS AS MODIFIERS OF THE PTEN PATHWAY AND METHODS OF USE

Human ADK genes are identified as modulators of the PTEN pathway, and thus are therapeutic targets for disorders associated with defective PTEN function. Methods for identifying modulators of PTEN, comprising screening for agents that modulate the activity of ADK are provided. La présente invention...

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Bibliographische Detailangaben
Hauptverfasser:	LICKTEIG, KIM, COSTA, MICHAEL, R, MCGRATH, GARTH, JOSEPH
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Human ADK genes are identified as modulators of the PTEN pathway, and thus are therapeutic targets for disorders associated with defective PTEN function. Methods for identifying modulators of PTEN, comprising screening for agents that modulate the activity of ADK are provided. La présente invention a trait à des gènes ADK humains identifiés en tant que modulateurs de la voie PTEN, et donc utiles en tant qu'agents thérapeutiques pour des troubles associés à une fonction déficiente de PTEN. L'invention a également trait à des procédés permettant l'identification de modulateurs de PTEN, comprenant le criblage pour des agents modulateurs de l'activité d'adénosine kinase.