GUANIDINO-SUBSTITUTED QUINAZOLINONE COMPOUNDS AS MC4-R AGONISTS

A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structure IA, IB, and IC where the values of the variables are defined here...

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Bibliographische Detailangaben
Hauptverfasser:	THOMPSON, BRIAN, D, SPEAKE, JASON, D, AURRECOECHEA, NATALIA, CHU, DANIEL, DE ARMAS KUNTZ, JUDITH, CHAUDER, BRIAN, A, DU, KIEN, S, SMITH, AARON, MUSSO, DAVID, L, SWAIN, WILLIAM, R, BOYCE, RUSTUM, S, CONLEE, CHRISTOPHER, R, THOMSON, STEPHEN, A, BARVIAN, KEVIN, K, BISHOP, MICHAEL, J
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structure IA, IB, and IC where the values of the variables are defined herein. L'invention concerne une variété de petites molécules contenant de la guanidine, ces molécules pouvant agir comme agonistes du récepteur MC4-R. Les composés selon l'invention peuvent être administrés à des sujets en traitement de maladies à médiation par le récepteur MC4-R. Lesdits composés possèdent la structure IA, IB et IC, les valeurs des variables étant telles que définies dans la description.