FEEDBACK-RESISTANT MEVALONATE KINASES

The present invention relates to modified mevalonate kinases that are less sensitive to feedback inhibition, and to polynucleotides encoding them. The invention further pertains to vectors comprising these polynucleotides and host cells containing such vectors. The invention provides a method for pr...

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Bibliographische Detailangaben
Hauptverfasser:	LEHMANN, MARTIN, HUEMBELIN, MARKUS, LOPEZ-ULIBARRI, RUAL, WYSS, MARKUS, BAI, RENYUNAN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to modified mevalonate kinases that are less sensitive to feedback inhibition, and to polynucleotides encoding them. The invention further pertains to vectors comprising these polynucleotides and host cells containing such vectors. The invention provides a method for producing the modified enzyme and a method for producing isoprenoid compounds. Mévalonate kinases qui sont moins sensibles à la rétro-inhibition et polynucléotides codant lesdites mévalonate kinases. La présente invention concerne en outre des vecteurs contenant ces polynucléotides et des cellules hôtes contenant ces vecteurs. Elle concerne encore une méthode de production de l'enzyme modifiée et une méthode de production de composés isoprénoïdes.