AMPHIPHILIC TRISULFONATED PORPHYRAZINES FOR PHOTODYNAMIC APPLICATIONS IN MEDICINE

Disclosed herein are novel trisulfonated tribenzo-mononahptho-porphyrazines, processes for making them and their application as improved photosensitizing drugs for the treatment of various medical conditions by photodynamic therapy (PDT). These water-soluble amphiphilic porphyrazines are substituted...

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Bibliographische Detailangaben
Hauptverfasser:	VAN LIER, JOHANNES E, TIAN, HONGJIAN, ALI, HASRAT, HASSESSIAN, HAROUTIOUN MINAS, CAUCHON, NICOLE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ADHESIVES CHEMISTRY DYES HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE LAKES MEDICAL OR VETERINARY SCIENCE METALLURGY MISCELLANEOUS APPLICATIONS OF MATERIALS MISCELLANEOUS COMPOSITIONS MORDANTS NATURAL RESINS ORGANIC CHEMISTRY ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES PAINTS POLISHES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Disclosed herein are novel trisulfonated tribenzo-mononahptho-porphyrazines, processes for making them and their application as improved photosensitizing drugs for the treatment of various medical conditions by photodynamic therapy (PDT). These water-soluble amphiphilic porphyrazines are substituted with different alkylyl, aryl, aminoalkyl and aminoaryl groups, with or without carboxyl moeity. L'invention concerne de nouvelles tribenzo-mononahptho-porphyrazines trisulfonées, ainsi que leurs procédés de production et leur application en tant que médicaments photosensibilisants dans le traitement de nombreux états pathologiques médicaux par thérapie photodynamique (TPD). Lesdites porphyrazines amphiphiles, solubles dans l'eau sont substituées par différents groupes alkylyle, aryle, aminoalkyle et aminoaryle, avec ou sans fraction carboxyle.