CRYSTAL OF PDE5, ITS CRYSTAL STRUCTURE AND ITS USE IN DRUG DESIGN

The present invention relates to the soakable crystals of a phosphodiesterase 5 (PDE5) and their uses in identifying PDE5 ligands, including PDE5 ligands and inhibitor compounds. The present invention also relates to methods of identifying such PDE5 inhibitor compounds and their medical use. The pre...

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Hauptverfasser:	GROOM, COLIN, ROGER, TAYLOR, WENDY, ELAINE, KAMP, SARAH, HELEN, HOPKINS, ANDREW, LEE, ROBINSON, COLIN, MARK, O'GARA, MARGARET, MARY, RINGROSE, HEATHER, JOAN, JENKINS, TIMOTHY, MARK, BROWN, DAVID, GRAHAM
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to the soakable crystals of a phosphodiesterase 5 (PDE5) and their uses in identifying PDE5 ligands, including PDE5 ligands and inhibitor compounds. The present invention also relates to methods of identifying such PDE5 inhibitor compounds and their medical use. The present invention additionally relates to crystals of PDE5 into which ligands may be soaked and crystals of PDE5 10 comprising PDE5 ligands that have been soaked into the crystal. La présente invention concerne les cristaux absorbables d'une phosphodiestérase 5 (PDE5) et leurs utilisations pour identifier des ligands de PDE5, y compris des composés inhibiteurs de PDE5. La présente invention concerne également des méthodes pour identifier ces composés inhibiteurs, ainsi que leur usage médical. Elle concerne d'autre part des cristaux PDE5 dans lesquels des ligands peuvent être absorbés, et des cristaux de PDE5 renfermant des ligands de PDE5 ayant été absorbés dans le cristal.