REGULATION OF GUANINE NUCLEOTIDE EXCHANGE FACTOR

The invention relates generally to the methods of treating brain diseases and compounds for treating brain diseases, and more specifically relates to using compounds that are able to modulate guanine nucleotide exchange factors for proteins belonging to the Rap family of small GTPases to treat disea...

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Bibliographische Detailangaben
Hauptverfasser:	GIBSON, LUCIEN, CHARLES, DONALD, MACKENZIE, SIMON, JOHN, MCFARLANE, MORAG, COOREMAN, ANN, KEWNEY, JUSTIN, PETER, MCPHEE, IAN, BRESLIN, CATHERINE, HAMMOND, STEPHEN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	The invention relates generally to the methods of treating brain diseases and compounds for treating brain diseases, and more specifically relates to using compounds that are able to modulate guanine nucleotide exchange factors for proteins belonging to the Rap family of small GTPases to treat diseases of the brain, such as Alzheimer's and Schizophrenia. L'invention concerne généralement des procédés de traitement de maladies cérébrales, des composés pour le traitement de maladies cérébrales, et plus spécifiquement l'utilisation de composés pour moduler les facteurs d'échange du nucléotide guanine pour les protéines appartenant à la famille Rap des petites GTPases, pour le traitement de maladies cérébrales, telles que la maladie d'Alzheimer et la schizophrénie.