NEW SULFONYL DERIVATIVES OF AMINONAPHTOLS

The present invention relates to new compounds of formula I, [Chemical formula should be inserted here. Please see paper copy] wherein R1, R2, R3, R4 and R5 are as defined as in formula I, or salts, solvates or solvated salts thereof, a process for their preparation, pharmaceutical compositions cont...

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Bibliographische Detailangaben
Hauptverfasser:	BESIDSKI, YEVGENI, NYSTROEM, JAN-ERIK
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to new compounds of formula I, [Chemical formula should be inserted here. Please see paper copy] wherein R1, R2, R3, R4 and R5 are as defined as in formula I, or salts, solvates or solvated salts thereof, a process for their preparation, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy. The compounds are vanilloid receptor 1 (VR1) inhibitors and are useful in the treatment of a number of different disorders, for example acute and chronic neuropathic and inflammatory pain. L'invention concerne des composés de formule I, dans laquelle R1, R2, R3, R4 et R5 sont tels que définis, y compris les sels, solvates ou sels solvatés correspondants. L'invention concerne également un procédé d'élaboration correspondant, des compositions pharmaceutiques renfermant ces composés, et l'utilisation des composés en question à des fins thérapeutiques. Lesdits composés sont des inhibiteurs de récepteur vanilloïde 1 (VR1) et ils sont utiles dans le traitement d'un certain nombre de troubles, par exemple la douleur neuropathique et inflammatoire aiguë et chronique.