METHOD AND APPARATUS FOR PATTERN IDENTIFICATION IN DIPLOID DNA SEQUENCE DATA

This invention provides methods for identifying mutations and methylation patterns in diploid DNA sequence signal data. In particular, the invention provides methods for (1) obtaining two parental allele sequences from diploid DNA sequence signal data, (2) identifying the mutation and haplotype patt...

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Bibliographische Detailangaben
Hauptverfasser:	MAGNESS, CHARLES, LEE, SUN, DAKE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CALCULATING CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPUTING CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES COUNTING ELECTRIC DIGITAL DATA PROCESSING ENZYMOLOGY INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	This invention provides methods for identifying mutations and methylation patterns in diploid DNA sequence signal data. In particular, the invention provides methods for (1) obtaining two parental allele sequences from diploid DNA sequence signal data, (2) identifying the mutation and haplotype patterns in the two parental allele sequences, (3) assigning likelihood scores for the mutations thus identified, and (4) identifying patterns of methylation. Cette invention concerne des méthodes d'identification de modèles de mutation et de méthylation dans des données de signalisation de séquences d'ADN diploïde. L'invention concerne en particulier des méthodes qui permettent: 1) d'obtenir deux séquences allèles parentales à partir des données de signalisation de séquences d'ADN diploïde; 2) d'identifier le modèle de mutation et le modèle d'haplotype dans les séquences allèles parentales; 3) d'effectuer des calculs de probabilité pour les mutations ainsi identifiées; et 4) d'identifier des modèles de méthylation.