PIRAZOLE MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
The present invention relates to pyrazoles of formula (I) which are modulators of ATPBinding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also re...
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| creator | SINGH, ASHVANI, K OLSON, ERIC, R CHAMBERS, FRED, III LIU, YAHUA GONZALEZ, JESUS, E., III GROOTENHUIS, PETER HADIDA RUAH, SARAH, S MILLER, MARK, T MAKINGS, LEWIS, R VANGOOR, FREDERICK, F RADER, JAMES, A |
| description | The present invention relates to pyrazoles of formula (I) which are modulators of ATPBinding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
La présente invention concerne des pyrazoles de formule (I), qui sont des modulateurs de transporteurs de cassettes de liaison à l'ATP ("ABC") ou leurs fragments, y compris le régulateur transmembranaire de la fibrose kystique ("CFTR"), leurs compositions et des méthodes qui leur sont associées. L'invention concerne également des méthodes de traitement de maladies induites par les transporteurs ABC mettant en oeuvre lesdits modulateurs. |
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La présente invention concerne des pyrazoles de formule (I), qui sont des modulateurs de transporteurs de cassettes de liaison à l'ATP ("ABC") ou leurs fragments, y compris le régulateur transmembranaire de la fibrose kystique ("CFTR"), leurs compositions et des méthodes qui leur sont associées. L'invention concerne également des méthodes de traitement de maladies induites par les transporteurs ABC mettant en oeuvre lesdits modulateurs.</description><edition>7</edition><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040923&DB=EPODOC&CC=WO&NR=2004080972A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040923&DB=EPODOC&CC=WO&NR=2004080972A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SINGH, ASHVANI, K</creatorcontrib><creatorcontrib>OLSON, ERIC, R</creatorcontrib><creatorcontrib>CHAMBERS, FRED, III</creatorcontrib><creatorcontrib>LIU, YAHUA</creatorcontrib><creatorcontrib>GONZALEZ, JESUS, E., III</creatorcontrib><creatorcontrib>GROOTENHUIS, PETER</creatorcontrib><creatorcontrib>HADIDA RUAH, SARAH, S</creatorcontrib><creatorcontrib>MILLER, MARK, T</creatorcontrib><creatorcontrib>MAKINGS, LEWIS, R</creatorcontrib><creatorcontrib>VANGOOR, FREDERICK, F</creatorcontrib><creatorcontrib>RADER, JAMES, A</creatorcontrib><title>PIRAZOLE MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS</title><description>The present invention relates to pyrazoles of formula (I) which are modulators of ATPBinding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
La présente invention concerne des pyrazoles de formule (I), qui sont des modulateurs de transporteurs de cassettes de liaison à l'ATP ("ABC") ou leurs fragments, y compris le régulateur transmembranaire de la fibrose kystique ("CFTR"), leurs compositions et des méthodes qui leur sont associées. L'invention concerne également des méthodes de traitement de maladies induites par les transporteurs ABC mettant en oeuvre lesdits modulateurs.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAI8AxyjPL3cVXw9XcJ9XEM8Q8KVvB3U3AMCdB18vRz8fRzV3B2DA52DQlxVQgJcvQLDvAPCnENCuZhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGBiYGFgaW5kaOhsbEqQIANl0p1A</recordid><startdate>20040923</startdate><enddate>20040923</enddate><creator>SINGH, ASHVANI, K</creator><creator>OLSON, ERIC, R</creator><creator>CHAMBERS, FRED, III</creator><creator>LIU, YAHUA</creator><creator>GONZALEZ, JESUS, E., III</creator><creator>GROOTENHUIS, PETER</creator><creator>HADIDA RUAH, SARAH, S</creator><creator>MILLER, MARK, T</creator><creator>MAKINGS, LEWIS, R</creator><creator>VANGOOR, FREDERICK, F</creator><creator>RADER, JAMES, A</creator><scope>EVB</scope></search><sort><creationdate>20040923</creationdate><title>PIRAZOLE MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS</title><author>SINGH, ASHVANI, K ; OLSON, ERIC, R ; CHAMBERS, FRED, III ; LIU, YAHUA ; GONZALEZ, JESUS, E., III ; GROOTENHUIS, PETER ; HADIDA RUAH, SARAH, S ; MILLER, MARK, T ; MAKINGS, LEWIS, R ; VANGOOR, FREDERICK, F ; RADER, JAMES, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2004080972A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2004</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SINGH, ASHVANI, K</creatorcontrib><creatorcontrib>OLSON, ERIC, R</creatorcontrib><creatorcontrib>CHAMBERS, FRED, III</creatorcontrib><creatorcontrib>LIU, YAHUA</creatorcontrib><creatorcontrib>GONZALEZ, JESUS, E., III</creatorcontrib><creatorcontrib>GROOTENHUIS, PETER</creatorcontrib><creatorcontrib>HADIDA RUAH, SARAH, S</creatorcontrib><creatorcontrib>MILLER, MARK, T</creatorcontrib><creatorcontrib>MAKINGS, LEWIS, R</creatorcontrib><creatorcontrib>VANGOOR, FREDERICK, F</creatorcontrib><creatorcontrib>RADER, JAMES, A</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SINGH, ASHVANI, K</au><au>OLSON, ERIC, R</au><au>CHAMBERS, FRED, III</au><au>LIU, YAHUA</au><au>GONZALEZ, JESUS, E., III</au><au>GROOTENHUIS, PETER</au><au>HADIDA RUAH, SARAH, S</au><au>MILLER, MARK, T</au><au>MAKINGS, LEWIS, R</au><au>VANGOOR, FREDERICK, F</au><au>RADER, JAMES, A</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PIRAZOLE MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS</title><date>2004-09-23</date><risdate>2004</risdate><abstract>The present invention relates to pyrazoles of formula (I) which are modulators of ATPBinding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
La présente invention concerne des pyrazoles de formule (I), qui sont des modulateurs de transporteurs de cassettes de liaison à l'ATP ("ABC") ou leurs fragments, y compris le régulateur transmembranaire de la fibrose kystique ("CFTR"), leurs compositions et des méthodes qui leur sont associées. L'invention concerne également des méthodes de traitement de maladies induites par les transporteurs ABC mettant en oeuvre lesdits modulateurs.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PIRAZOLE MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS |
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