PIRAZOLE MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

PIRAZOLE MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

The present invention relates to pyrazoles of formula (I) which are modulators of ATP­Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also re...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: SINGH, ASHVANI, K, OLSON, ERIC, R, CHAMBERS, FRED, III, LIU, YAHUA, GONZALEZ, JESUS, E., III, GROOTENHUIS, PETER, HADIDA RUAH, SARAH, S, MILLER, MARK, T, MAKINGS, LEWIS, R, VANGOOR, FREDERICK, F, RADER, JAMES, A
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present invention relates to pyrazoles of formula (I) which are modulators of ATP­Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators. La présente invention concerne des pyrazoles de formule (I), qui sont des modulateurs de transporteurs de cassettes de liaison à l'ATP ("ABC") ou leurs fragments, y compris le régulateur transmembranaire de la fibrose kystique ("CFTR"), leurs compositions et des méthodes qui leur sont associées. L'invention concerne également des méthodes de traitement de maladies induites par les transporteurs ABC mettant en oeuvre lesdits modulateurs.