TARGETS FOR CONTROLLING CELLULAR GROWTH AND FOR DIAGNOSTIC METHODS

A method of identifying a compound that induces apoptosis is disclosed. The method includes identifying compounds that inhibit the expression and/or activity of a target. Also disclosed are methods for inducing apoptosis by inhibiting one of the targets. The invention further includes methods for th...

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Bibliographische Detailangaben
Hauptverfasser:	GELMAN, MARINA, AXENOVICH, SERGEY, A, NG, DEAN, STULL, ROBERT, CHUI, KITTY
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	A method of identifying a compound that induces apoptosis is disclosed. The method includes identifying compounds that inhibit the expression and/or activity of a target. Also disclosed are methods for inducing apoptosis by inhibiting one of the targets. The invention further includes methods for the diagnosis of a tumor that include determining the level of at least one of the targets as a biomarker in a patient sample, the level of the biomarker being indicative of the presence of tumor cells. L'invention concerne une méthode permettant d'identifier un composé qui induit l'apoptose. Cette méthode consiste à identifier des composés qui inhibent l'expression et/ou l'activité d'une cible. L'invention concerne également des méthodes permettant d'induire l'apoptose en inhibant une des cibles. L'invention concerne enfin des méthodes permettant de diagnostiquer une tumeur. Ces méthodes consistent à déterminer le taux d'au moins une des cibles utilisée comme biomarqueur dans un échantillon de patient, le taux du biomarqueur étant représentatif de la présence de cellules tumorales.