COMPOUND LIBRARIES OF IMIDAZO[1,5-A]PYRIDIN-3-YL DERIVATIVES AND RELATED HETEROBICYCLES FOR TARGETTING COMPOUNDS CAPABLE OF BINDING TO G-PROTEIN COUPLED RECEPTORS

COMPOUND LIBRARIES OF IMIDAZO[1,5-A]PYRIDIN-3-YL DERIVATIVES AND RELATED HETEROBICYCLES FOR TARGETTING COMPOUNDS CAPABLE OF BINDING TO G-PROTEIN COUPLED RECEPTORS

The present invention provides a library designed to take advantage of a common recognition feature of G-protein coupled receptors, namely the 'benzhydryl' or 'rabbit ears' arrangement of aromatic rings. In addition the library utilises several themes common in GPCRs selecting fo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CROSSLEY, ROGER, MACRITCHIE, JACQUELINE, ANNE, WARD, TERENCE
Format: Patent
Sprache:eng ; fre
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
COMBINATORIAL CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention provides a library designed to take advantage of a common recognition feature of G-protein coupled receptors, namely the 'benzhydryl' or 'rabbit ears' arrangement of aromatic rings. In addition the library utilises several themes common in GPCRs selecting for subsets which recognise basic and 'acidic' ligands. The library comprises or consists of a set of structurally related compounds of general formulae (A)or (B). The present invention also provides intermediates (formula (3)). L'invention porte sur une bibliothèque conçue pour tirer avantage de traits communs de reconnaissance des récepteurs couplés à la protéine G (GPCRS), c.-à-d. les arrangements "benzhydryle" ou en V de cycles aromatiques. De plus la bibliothèque utilise plusieurs thèmes communs aux GPCRS pour la sélection de sous-ensembles reconnaissant les liants basiques et acides. La bibliothèque consiste en ou comporte un ensemble de composés de structures apparentées de formule générale (A).