NEW ALPHA-GLUCOSIDASE INHIBITORS AND THEIR SYNTHESIS FROM A NATURAL SOURCE

The present invention provides novel a-glucosidase inhibitory compound (-)-mesquitol and its analogs isolated in significant yield from traditional medicinal plant Dichrostachys cinerea and further modification of (-)-mesquitol to enhance the a-glucosidase inhibitory potential; the invention also identifies the usage of (-)-mesquitol and its analogues, based on their a-glucosidase inhibitory activity, as broad based potential therapeutics as antihyperglycemic, antidiabatic, antiobesity, antiviral, anticancer, immunestimulants and the like. La présente invention concerne, d'une part, un nouveau composé inhibiteur de l' alpha -glucosidase, le (-)-mesquitol, et ses analogues, isolés en grande quantité à partir d'une plante médicinale traditionnelle, Dichrostachys cinerea, et, d'autre part, la modification du (-)-mesquitol pour augmenter le potentiel inhibiteur de l' alpha -glucosidase du composé. L'invention concerne également l'utilisation du (-)-mesquitol et de ses analogues, sur la base de leur activité inhibitrice de l' alpha -glucosidase, comme agents thérapeutiques à large spectre, y compris comme agents antihyperglycémiants, antidiabétiques, antiobésité, antiviraux, anticancéreux, immunostimulants et analogues.