GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE-S(GAPDS), A GLYCOLYTIC ENZYME EXPRESSED ONLY IN MALE GERM CELLS,IS A TARGET FOR MALE CONTRACEPTION

Methods for identifying modulators of a male germ cell-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) are disclosed. Also disclosed are methods for screening potential modulators for an ability to 5 modulate biological functions of a GAPDS polypeptide. L'invention concerne des procéd...

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Hauptverfasser:	O'BRIEN, DEBORAH, A, EDDY, PH., D., EDWARD, M
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Zusammenfassung:	Methods for identifying modulators of a male germ cell-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) are disclosed. Also disclosed are methods for screening potential modulators for an ability to 5 modulate biological functions of a GAPDS polypeptide. L'invention concerne des procédés d'identification de modulateurs d'une glycéraldéhyde 3-phosphate déhydrogénase (GAPDS) spécifique d'une cellule germinale mâle. L'invention concerne en outre des procédés de criblage de modulateurs potentiels, aptes à moduler les fonctions biologiques d'un polypeptide GAPDS.