ACE-INHIBITORS HAVING ANTIOXIDANT AND NITRICOXID-DONOR ACTIVITY

Multifonctional ACE inhibitor compounds are provided, that combine ACE-inhibiting activity with capability to scavenge superoxide and other reactive oxygen species, and that may further function as nitric oxide donors. The compounds are useful for preventing or treating various disorders, including...

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Bibliographische Detailangaben
Hauptverfasser:	HAJ-YEHIA, ABDULLAH, IBRAHIM, KHAN, MOHAMED, AMIN, QADRI, BASHIR, ALI
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Multifonctional ACE inhibitor compounds are provided, that combine ACE-inhibiting activity with capability to scavenge superoxide and other reactive oxygen species, and that may further function as nitric oxide donors. The compounds are useful for preventing or treating various disorders, including cardiovascular, and diabetes associated disorders. L'invention concerne des composés inhibiteurs d'enzyme de conversion de l'angiotensine multifonctionnels qui combinent l'activité d'inhibition de l'enzyme de conversion de l'angiotensine pouvant piéger le superoxyde et d'autres espèces d'oxygène réactifs, et fonctionner par la suite en tant que donneurs d'oxydes nitriques. Les composés de l'invention sont utiles dans la prévention ou le traitement de divers troubles, notamment des troubles cardiovasculaires et ceux associés aux diabètes.